Evaluation of the influence of Inosine pranobex on the matrix protein system in patients with chronic viral cervicitis

The reproductive potential of both women and men is declining every year. Many factors contribute to the violation function – chemical, physical, mechanical, psychogenic, however, biological have most pronounced effect on reproduction. Chronic viral cervicitis can be not only cause infertility losses, but also development intraepithelial dysplasia, as well cervical cancer. PVI, a monoinfection, quite rare along with HPV. Other UGIs (urogenital infections) act common routes transmission entry gates. association PVI herpesvirus infection. An increase in MMP, systemically at local level, may indicate cell modeling processes, which contributes autoimmune inflammation further destruction tissues tract. Activation MMP promotes release HSV from nerve ganglia reactivation Therapy for HPV HVI (herpes virus are debatable. There no single standard treatment, there number drugs that antiviral immunomodulatory effects. Currently, studies dynamics infection state MMPs TIMPs during Inosine pranobex therapy. Objective: evaluate changes matrix metalloproteinases 2 9 their tissue inhibitors types 1 patients human papillomavirus herpes infections after 6 herpetic were examined treated containing active ingredient pranobex. levels MMP-2, MMP-9 TIMP-1, TIMP-2 blood serum determined using specific reagents R&D Diagnostics Inc. (USA). indicators showed decrease level MMP-9, TIMP-1 simultaneous relative values before In HVI, therapy MMP-2 levels, content an TIMP-2. Prior use therapy, ratio main groups comparison control group was found, largest found infections. After positive established groups. Thus, I decreased became equal values. II patients, ratio, despite decrease, remained higher than women.